研究業績

2026年

原著論文

• "Genomic analysis of dental pulp mesenchymal stromal cells for therapeutic applications"
  Hirai K, Nitahara-Kasahara Y, Okamoto Y, Sangu N, Aizen Y, Watanabe A, Okada T
  Regenerative Therapy (2026).

  • URL
  • DOI: 10.1016/j.reth.2026.101080
• "Tumor-targeted adeno associated virus-loaded complexes comprising tannic acid and phenylboronic acid-polymers for orthotopic glioblastoma therapy."
  Matsudaira N, Honda Y, Kinoh H, Liu X, Nagao S, Matsutomo-Nitta S, Haochen G, Hayashita-Kinoh H, Aizawa M, Muguruma K, Miura Y, Shishido A, Okada T, Nishiyama N.J.
  J Control Release (2026).

  • DOI: 10.1016/j.jconrel.2025.114477
• "Digital Outcome Measures for Gait and Spontaneous Locomotor Activity in Dystrophic Dogs"
  Kuraoka M, Watanabe K, Kawashima T, Nitahara-Kasahara Y, Tachimori H, Takeda S, Minegishi K, Aoki Y
  Methods Mol Biol. 2963, 213-223 (2026).

  • DOI: 10.1007/978-1-0716-4738-7_16
• "sgRNA Amount is a Limiting Factor in Adenine Base Editing using RNA LNPs"
  Birkenshaw A, Thomson T, Truong MP, Komaki Y, Ramsden N, Timpano A, Huang C, Blakney AK, Kurek DZ, Kulkarni J, Ross CJD.
  (2026).

  • DOI: 10.1016/j.omtn.2026.102909

国内誌・総説

• "バイオリアクターによる遺伝子治療、再生医療、バイオ医薬品の生産"
  和田 美加子、松田 孝彦、岡田 尚巳
  (2026).
• "筋ジストロフィーに対する間葉系間質細胞を用いた抗炎症療法"
  笠原 優子、岡田 尚巳
  (2026).

2025年

原著論文

• "Optimizing activation and culture conditions for the production of cord blood-derived CAR-T and natural killer cells"
  Nakamura N, Liao J, Soda Y, Takahashi M, Kodera H, Kobari Y, Hirai Y, Takaori-Kondo A, Okada T
  Br J Haematol. (2025).

  • DOI: 10.1111/bjh.70139
• "Identification of coexisting Mfrprd6 and Pde6brd10 mutations causing spontaneous retinal detachment in commercially available rd6 mice"
  Shiozawa AL, Hosoi Kobayashi M , Shiozawa Y, Ikeda Y, Miyagawa Y, Okamoto F, Sakai M, Okada T, Igarashi T
  PLoS One 20, 9, e0332446 (2025).

  • DOI: 10.1371/journal.pone.0332446
• "Carbohydrate sulfotransferase 14 gene deletion induces dermatan sulfate deficiency and affects collagen structure and bowel contraction"
  Ono F, Takahashi Y, Shimada S, Mizumoto S, Miyata S, Nitahara-Kasahara Y, Yamada S, Okada T, Kosho T, Yoshizawa T
  PLoS One 20, 5, e0320943 (2025).

  • DOI: 10.1371/journal.pone.03
• "Evasion of APOBEC1-mediated Intrinsic Immunity by a Herpesvirus Uracil DNA Glycosylase"
  Kato A, Harima H, Tsunekawa Y, Igarashi M, Kitamura K, Wakae K, Nishiyama T, Morimoto S, Suzuki T, Kozuka-Hata H, Oyama M, Motooka D, Watanabe M, Takeshima K, Maruzuru Y, Koyanagi N, Okano H, Inada T, Okada T, Muramatsu M, Kawaguchi Y
  (2025).
• "Increased relative eosinophil counts portend neck oedema after chimeric antigen receptor-T therapy"
  Nakamura N, Jo T, Arai Y, Kitawaki T, Nishikori M, Mizumoto C, Kanda J, Yamashita K, Nagao M, Takaori-Kondo A
  Br J Haematol (2025).
• "A Novel MiRNA Detection System Combining TWJ-SDA, Multistep L-TEAM, and CRISPR-Cas3"
  Miyazaki R, Aibara K, Isse H, Kashiwai F, Takahashi M, Onodera A, Tsunekawa Y, Yamauchi Y, Yoshimi K, Mashimo T, Komiya K, Okada T
  bioRxiv [Preprint]. (2025).

  • URL
  • DOI: 10.1101/2025.09.25.678453

国内誌・総説

• "筋ジストロフィーに対する間葉系間質細胞を用いた抗炎症療法"
  笠原 優子、岡田 尚巳
  (2025).

2024年

原著論文

• "Purification of adeno-associated viral vector serotype 9 using ceramic hydroxyapatite chromatography and its analysis"
  Kurosawa Y, Tsunekawa Y, Wada M, Aizen Y, Nitahara-Kasahara Y, Okada T
  Curr Protoc (2024).
• "Enhanced Discriminability of Viral Vectors in Viscous Nanopores"
  Tsutsui M, Tsunekawa Y, Wada M, Arima A, Onodera A, Nishina M, Nagoya M, Baba Y, Kawai T, Okada T
  Small Methods (2024).
• "Immunocompetent murine glioblastoma stem-like cell models exhibiting distinct phenotypes"
  Kardani K, Ghouse SM, Jabbar MAD, Rajasubramanian N, Gil JS, Stemmer-Rachamimov A, Soda Y, Martuza RL, Hara T, Wakimoto H, Rabkin SH
  Neuro-Oncology Advances (2024).
• "Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa"
  Onishi A, Tsunekawa Y, Mandai M, Ishimaru A, Ohigashi Y, Sho J, Yasuda K, Suzuki K, Izpisua Belmonte JC, Matsuzaki F,
  (2024).
• "Mesenchymal stem cell origin contributes to the antitumor effect of oncolytic virus carriers"
  Sukegawa M, Miyagawa Y, Kuroda S, Yamazaki Y, Yamamoto M, Adachi K, Sato H, Sato Y, Taniai N, Yoshida H, Umezawa A, Sakai M, Okada T
  Mol Ther Oncol (2024).
• "Characterization of disease-specific alterations in metabolites and effects of mesenchymal stromal cells on dystrophic muscles"
  Nitahara-Kasahara Y, Posadas Herrera G, Hirai K, Oda Y, Snagu-Miyamoto N, Yamanashi Y, Okada T
  Front Cell Dev Biol (section Stem Cell Research) (2024).
• "Identifying viral vector characteristics by nanopore sensing"
  Tsutsui M, Wada M, Arima A, Tsunekawa Y, Sasaki T, Sakamoto K, Yokota K, Baba Y, Kawai T, Okada T
  ACS Nano (2024).

国内誌・総説

• "デュシェンヌ型筋ジストロフィーに対する遺伝子細胞治療"
  喜納(早下)裕美、笠原優子、岡田尚巳
  金沢大学十全医学学会雑誌 (2024).
• "アデノ随伴ウイルスベクターワクチンの開発"
  菅生健、岡田尚巳
  Drug Delivery System 34, 4, 242-247 (2024).